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TRIBENZOR® has been proven to help lower blood pressure.

The Right Fit Blood
Pressure Program.

Join now for: Savings—a monthly co-pay for eligible patients that may be no more than $25.* Plus tips, tools, advice from the Mayo Clinic, a blood pressure support line, and other patient support services.

*Terms of use and exclusions apply.


TRIBENZOR is a prescription medicine used to lower high blood pressure (hypertension). Medicines that lower blood pressure lower the chance of having a stroke or heart attack. TRIBENZOR is not for use as the first medicine to treat high blood pressure.

Patients may require more than one type of blood pressure lowering medication. Along with lowering blood pressure, a complete treatment plan to lower the chance of a stroke or heart attack may include exercise, a diet low in sodium, stopping smoking, controlling cholesterol, treatment or prevention of blood clots, and controlling blood sugar.

Important Safety Information for TRIBENZOR®


  • TRIBENZOR can cause harm or death to an unborn baby
  • Talk with your doctor about other ways to lower your blood pressure if you become pregnant
  • If you get pregnant while taking TRIBENZOR, tell your doctor immediately

Please see the WARNINGS AND PRECAUTIONS section of the Full Product Information about Fetal Toxicity.

Do not take TRIBENZOR if you:

  • Take medicine that contains aliskiren and you have diabetes or kidney problems
  • Have less urine than normal or if you cannot urinate
  • Are allergic to other sulfonamide type medicines
  • Have severe kidney disease

Before taking TRIBENZOR, tell your doctor if you are pregnant or plan to become pregnant. Also tell your doctor if you are breast-feeding or plan to breast-feed. A medicine in TRIBENZOR can pass into your breast milk. This may harm your baby. You and your doctor should decide if you will take TRIBENZOR or breast-feed. You should not do both.

Let your doctor know about any health conditions you may have
Tell your doctor if you are allergic to any of the ingredients in TRIBENZOR (see Full Product information for a list of the ingredients in TRIBENZOR). Also let your doctor know if you have any of the health conditions listed below:

Before you take TRIBENZOR: Let your doctor know if you have these, or any other, medical conditions:
  • Kidney or liver problems
  • Lupus
  • Heart problems (including coronary heart disease and narrowing of the aortic valve)
  • A lot of diarrhea or are vomiting
  • History of allergy or bronchial asthma

Tell your doctor about all the medicines you take
Some of your other medicines and TRIBENZOR could affect each other. This may cause serious side effects.

These medicines may include prescription and nonprescription medicines, vitamins, and herbal supplements:

If you take TRIBENZOR, tell your doctor if you also take:

  • Water pills (diuretics)
  • Other medicines for high blood pressure or a heart problem
  • Potassium supplements or a salt substitute that contains potassium
  • Pain or arthritis medicines, such as aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Welchol® (colesevelam hydrochloride)
  • Diabetes medicine including insulin
  • Narcotic pain medicine
  • Sleeping pills and antiseizure medicines called barbiturates
  • Lithium for certain types of depression
  • Steroids
  • Cholesterol-lowering medicines (including simvastatin)

About alcohol and other drug interactions
If you are taking TRIBENZOR, do not drink alcohol. Your blood pressure may become too low if you drink alcohol.

Some of your other medicines and TRIBENZOR could affect each other. This may cause serious side effects. Take TRIBENZOR as prescribed by your doctor. Talk with your doctor before you stop taking TRIBENZOR.

Know about possible side effects of TRIBENZOR
Serious side effects may include injury or death to an unborn baby; low blood pressure (hypotension), which may cause you to feel faint or dizzy; and kidney problems, which may get worse in people with kidney disease. If you have kidney problems, you may need blood tests, and your doctor may need to lower your dose. Tell your doctor if you get swelling in your feet, ankles, or hands, or have unexplained weight gain. These may be signs of kidney problems. If you have heart failure, your doctor should also check your kidney function before prescribing these medicines. Tell your doctor if you are experiencing these symptoms.

Serious side effects may also include severe, chronic diarrhea with considerable weight loss, which may develop months to years after starting TRIBENZOR. Tell your doctor if you are experiencing these symptoms.

Additional side effects of TRIBENZOR
Because of amlodipine, an ingredient in TRIBENZOR, other serious side effects may include chest pain that gets worse or heart attack. Get medical help right away if you have chest pain that gets worse or does not go away. TRIBENZOR also contains a thiazide diuretic (water pill), which may cause allergic reactions and changes in body salts (such as sodium and potassium) and fluids. Tell your doctor if you have signs of a change in body salts and body fluids. Signs of a change include: dry mouth, thirst, weakness, tiredness or sleepiness, or restlessness. These signs may also include confusion, seizures, muscle pains or cramps, muscle tiredness, dizziness or fainting, having little or no urine, fast heartbeat, and nausea and vomiting.

The thiazide diuretic in TRIBENZOR can also cause eye problems which may lead to vision loss. Symptoms can happen within hours to weeks of starting TRIBENZOR. Tell your doctor right away if you have decrease in vision or eye pain.

The most common side effects of TRIBENZOR include dizziness; swelling of the ankles, feet, and hands; headache; tiredness; stuffy or runny nose and sore throat; muscle twitching (spasms); nausea; upper respiratory tract infection; diarrhea; urinary tract infection; and swelling of the joints.

Tell your doctor if you have any side effect that bothers you or does not go away. Not all the possible side effects of TRIBENZOR have been mentioned in the Important Safety Information. For more information, talk with your doctor or pharmacist. Call your doctor for medical advice about side effects.

To report side effects, contact Daiichi Sankyo, Inc., at 1-877-437-7763 or the FDA at 1-800-332-1088 or

Please see Full Prescribing Information for TRIBENZOR, including Boxed WARNING regarding Fetal Toxicity.

The photos depict models, not actual patients or healthcare professionals.